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KMID : 0939920180500041462
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대한암학회지
2018 Volume.50 No. 4 p.1462 ~ p.1466
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Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy
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Hu Yongxian
Wang Jiasheng
Pu Chengfei
Zhao Kui
Cui Qu
Wei Guoqing
Wu Wenjun
Xiao Lei
Xiao Yang
Wang Jinping
Wu Zhao
Huang He
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Abstract
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Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied. Herein, for the first time we report a diffuse large B-cell lymphoma patient with terminal ileum involvement obtained rapid remission and developed spontaneous terminal ileal perforation 38 days following CART19 infusion. The late-onset perforation reminds us that, for the safety of CART treatment, more cautions are warranted for the management of delayed GI complications.
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KEYWORD
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Refractory/relapse, B-cell lymphoma, Chimeric antigen receptor T cells, Terminal ileal perforation
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